Further studies on a novel animal model of depression: therapeutic effects of a tricyclic antidepressant.
نویسندگان
چکیده
ROTH, K. A. AND R. J. KATZ. Further studies on a novel animal model of depression: Therapeutic effects of a tricyclic antidepressant. NEUROSCI. BIOBEHAV. REV. 5(2) 253-258, 1981.--We have previously shown that rats given stress before open field testing have elevated activity in comparison with unstressed rats. This acute behavioral response may be eliminated by chronic stress and restored by pretreatment with the monoamine oxidase inhibitor pargyline. The present study replicated previous findings upon the effects of acute and chronic stress and extended results upon treatment to the class of tricyclic antidepressant drugs, using imipramine as a prototypic tricyclic antidepressant. Imipramine also restored both behavioral and psychoendocrine activity which was otherwise altered by chronic stress.
منابع مشابه
Reconsidering GHB: orphan drug or new model antidepressant?
For six decades, the principal mode of action of antidepressant drugs is the inhibition of monoamine re-uptake from the synaptic cleft. Tricyclic antidepressants, selective serotonin re-uptake inhibitors (SSRIs) and the new generation of dual antidepressants all exert their antidepressant effects by this mechanism. In the early days of the monoaminergic era, other efforts have been made to amel...
متن کاملAntidepressant effects of hydroalcoholic extract of Alpinia officinarum rhizome on chronic unpredictable stress induced depression in BALB/c mice
Background: Alpinia officinarum is an aromatic plant that show some neuroprotective functions in animal models. Objective: This study aimed to evaluate the antidepressant effects of hydroalcoholic extract of A. officinarum rhizome using two behavioral models. Methods: Forty male BALB/c mice were randomized to four groups. All studygroups underwent three weeks of daily chronic unpredictable str...
متن کاملAntidepressant Activity of Methanolic Extract of Amaranthus Spinosus
Introduction: Depressive disorder is a prevalent psychiatric disorder, which affects 21% of the world population. The presently using drugs can impose a variety of side-effects including cardiac toxicity, hypopiesia, sexual dysfunction, body weight gain, and sleep disorder. During the last decade, there is a growing interest in the therapeutic effects of natural products on mental disorders. Am...
متن کاملAnimal research highlights a therapeutic potential of cannabinoids for the treatment of depression
Long known for their mood altering effects, cannabinoids are currently under investigation for their therapeutic potential in the treatment of depression. Findings from multiple areas of basic research indicate that this system is indeed a viable target for novel antidepressant drugs. Rodent models of depression have been shown to alter levels of the endogenous cannabinoids and the cannabinoid ...
متن کاملTreatment of Depression in the Elderly: A Systematic Review
Depression is a common symptom and a major public health problem in the elderly. Despite its prevalence and seriousness, depressive disorder in older people remains under-treated. The optimal treatment of depression in later life is crucial, and requires appreciation of several age-related factors such as comorbidity, polypharmacy, altered drug kinetics, variable treatment response and increase...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Neuroscience and biobehavioral reviews
دوره 5 2 شماره
صفحات -
تاریخ انتشار 1981